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AFFINILUTE MIP

Molecularly Imprinted Polymers - New, Selective Solid-Phase Extraction Materials
LC-GC Europe Article

A molekuláris lenyomatképzéssel szelektív adszorpciós helyeket hoznak létre egy polimer mátrixban, a mintamolekula (templát) jelenlétében történő polimerszintézis révén.
A molekuláris lenyomatot tartalmazó polimer (Molecularly Imprinted Polymer, MIP) a templát eltávolítása után képes a mintamolekula újrakötésére. A rendkívül szelektív extrakció révén igen tiszta extraktumok nyerhetők.

Affinilute MIP

 

Application Notes

Extraction of Triazines and Triazine Metabolites from Water Using AFFINILUTE MIP – Triazine

The following method has been developed for the extraction of the following triazines and triazine metabolites; atrazine, simazine, propazine, cyanazine, sebuthylazine, deisopropylatrazine, deethylatrazine, deethylterbutylazine, prometon and hydroxyterbutylazine from water. Recoveries are in the range 80-95% and are reproducible, allowing sharp decision limits. The maximum accepted level of triazines in drinking water is 0.1ug/L (EU legislation).

 

Extraction and Analysis of PAHs in Olive Oil Using AFFINILUTE MIP – PAH

This method demonstrates the extraction of a PAH standard test mix comprising of fluoranthene, benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(123-cd)pyrene, dibenzo(ah)anthracene, and benzo(ghi)perylene.

 

Extraction of Fluoroquinolones from Various Matrices Using AFFINILUTE MIP – Fluoroquinolones

The following methods have been developed and optimized for the extraction of fluoroquinolones (FQL) from a variety of sample matrixes including bovine kidney, honey, and milk. Example FQLs include sarafloxacin, norfloxacin, enrofloxacin, ciprofloxacin, lomefloxacin, and ofloxacin.

 

Extraction of Free and Total NNAL for LC-MS-MS Analysis Using AFFINILUTE MIP – NNAL

The following methods have been developed for the selective extraction of the tobacco specific nitrosamine, NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) from aqueous sample matrices such as biological fluids (e.g., urine). The method is highly reproducible and offers NNAL recoveries in the range of 90% and a limit of detection below 5 ppt.

 

Extraction of TSNAs from Urine Using AFFINILUTE MIP – TSNAs

The following methods have been developed for the selective extraction of tobacco specific nitrosamines (NNN, NNK, NAT, and NAB) from human urine. The method is highly reproducible and offers an average recovery of 80% (95% for NNK and NAT; and 70% for NNN and NAB). Detection limits of 4 pg/mL are readily achieved for urine samples using LC-MS-MS analysis.

 

Extraction of Chloramphenicol from Various Matrices Using AFFINILUTE MIP – Chloramphenicol

The following methods have been developed and optimized for the extraction of chloramphenicol from a variety of sample matrixes including milk, plasma, honey, urine, and shrimp/prawns for subsequent LC-MS/MS analysis. The methods are highly reproducible and offer low limits of detection.

 

Extraction of Amphetamines from Urine Using AFFINILUTE MIP – Amphetamines

The following method(s) have been developed for the class-selective extraction of Amphetamine, Methamphetamine, Phentermine, MDA, MDMA, MDEA from human urine. The method is highly reproducible and offers an average recovery greater than 80%.

 

Extraction of Beta-blockers from Urine and Other Biological Fluids Using AFFINILUTE MIP – β-blockers

The following methods have been developed for the selective extraction of β-blockers from both biological matrices and water. The methods are highly reproducible and offer β-blocker recoveries of > 80%. The method minimizes matrix effects and offers limits of detection of less than 5 ppt in water and less than 10 ppt for plasma and urine.

 

Extraction of β-agonists From Biological Matrices Using AFFINILUTE MIP – β-agonists

The following methods have been developed for the selective extraction of beta-agonists from biological matrices. Methods have been developed for both biological tissues (e.g. bovine muscle) and fluids (e.g. urine). The methods are highly reproducible and offer β-agonist recoveries in the range of 35-90%.

 

Extraction of Nitroimidazoles from Various Matrices Using AFFINILUTE MIP – Nitroimidazoles

These methods have been determined for Nitroimidazoles that can be optimized for a number of matrices. The nitroimidazoles that have been tested so far include: Dimetridazole (DMZ), Metronidazole (MNZ), Ipronidazole (IPZ), Ronidazole (RNZ); and their respective metabolites: DMZOH, MNZOH, and IPZOH.

 

Extraction of Clenbuterol from Urine Using AFFINILUTE MIP – Clenbuterol

The following methods have been developed for the selective extraction of clenbuterol from calf urine. The method is highly reproducible and offers clenbuterol recoveries of ≥ 70%.

 

Extraction of NSAIDs from Various Matrices Using AFFINILUTE MIP – NSAIDs

These methods have been determined for non-steroidal anti-inflammatory drugs (NSAIDs) that can be optimized for a number of matrices. The NSAIDs that have been tested so far include: Naproxen, Clofibric Acid, Diclofenac, and Ibuprofen.

 

Links

AFFINILUTE MIP Columns

 

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